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Biochemical and faecal markers
Edouard Louis further expounded on the use of faecal calprotectin and serum C-reactive protein (CRP) as the main biomarkers in IBD monitoring. Faecal calprotectin correlates with endoscopic lesions and the risk of relapse both in CD and UC and is currently the best marker available for mucosal inflammation. CRP correlates with disease activity, response to treatment and the risk of relapse in CD but often remains within normal range despite active disease in UC. CRP and faecal calprotectin are best used together with clinical assessment, to decide which patients require endoscopy or MRI before adapting treatment.