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How should new onset fulminant colitis be managed?
Accurate diagnosis, optimal medical therapy with glucocorticosteroids and cyclosporine or infliximab, and good timing of colectomy are vital in the management of new-onset fulminant colitis. Further, Paul Rutgeerts pointed out that short-term response can be achieved in more than 80% of steroid-refractory acute UC patients with either infliximab or cyclosporine within one week4. He recommended rescue therapy at day 5 - 7 with infliximab or cyclosporine in azathioprinenaïve patients, without switch or sequential use of these drugs.